This medicine is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.
How to use
To be used as directed by physician
Interactions / Warnings
Alcohol CAUTION It is unsafe to consume alcohol with It. Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes. warnings Pregnancy WEIGH RISKS VS BENEFITS It may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. warnings Lactation It is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby. Monitor the breastfed baby s blood sugar during treatment with It warnings Driving Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive. warnings Kidney CAUTION It should be used with caution in patients with kidney disease. Dose adjustment of It may be needed. Please consult your doctor. Use of It is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine. warnings Liver CAUTION It should be used with caution in patients with liver disease. Dose adjustment of It may be needed. Please consult your doctor. Use of It is not recommended in patients with severe liver disease.
