| Interactions / Warnings | Contraindicated in Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs, Concomitant use of an MAOI, or use within 14 days of MAOI discontinuation, Current or prior diagnosis of bulimia or anorexia nervosa, Hypersensitivity to buPROPion or any other component of the product, Seizure disorder. |
| Side Effects | Common Cardiovascular: Tachycardia (major depressive disorder, 11% ) Endocrine metabolic: Weight gain (2% to 9% ), Weight loss (major depressive disorder, 14% to 19% ) Gastrointestinal: Abdominal pain (2% to 9%), Constipation (5% to 10%), Nausea (13% to 18%), Xerostomia (17% to 26%) Neurologic: Confusion (major depressive disorder, 8% ), Dizziness (6% to 11%), Headache (25% to 34% ), Insomnia (11% to 20% ) Psychiatric: Agitation (2% to 9%) Respiratory: Nasopharyngitis (seasonal affective disorder, 13% ), Pharyngitis (major depressive disorder, 3% to 11% ), Upper respiratory infection (seasonal affective disorder, 9% ) Serious Cardiovascular: Complete atrioventricular block, Myocardial infarction Gastrointestinal: Colitis, Pancreatitis Hematologic: Pancytopenia Hepatic: Hepatitis, Jaundice, Liver damage, Liver function tests abnormal Immunologic: Anaphylactoid reaction, Anaphylaxis, Delayed hypersensitivity disorder Musculoskeletal: Rhabdomyolysis Neurologic: Seizure (major depressive disorder, 0.1% to 0.4% ) Ophthalmic: Angle-closure glaucoma Psychiatric: Delusional disorder, Depression, Worsening, Hallucinations, Hostile behavior (major depressive disorder, 6% ), Hypomania, Mania, Precipitation of episode, Paranoid ideation, Psychotic disorder, Activation, Suicidal behavior, Suicidal thoughts Respiratory: Pulmonary embolism Other: Angioedema. |
